Volume 1 Issue 1
Relationship between Otologic Symptoms, Headache, Depression and Temporomandibular Disorders
Rahena Akhter*, Nur Mohammad Monsur Hassan, Manabu Morita, and David Wilson
The etiology of temporomandibular disorder (TMD) is largely unknown. Some studies have been implicated that otologic symptoms are associated with the predisposition, initiation, and perpetuation of TMD. The aim is to investigate the associations of aural symptoms, headache and depression with the presence of TMD symptoms in young adults.
The Arrival of Synthetic Bone Grafts with Osteoinductive Potential
Richard J. Miron*, Yufeng Zhang
Bone grafting materials have played a pivotal role in modern dentistry. Used to fill bone defects and to augment missing or lost bone, a wide variety of bone grafts are now available including autogenous bone from the same donor, allografts harvested from human donors, xenografts harvested from an animal donor and a wide variety of synthetically fabricated bone grafts made from hydroxyappatite, tri-calcium phosphate, biphasic calcium phosphate and bioactive glasses.
Adsorption of Enamel Matrix Derivative to Bone Grafts: Is the Devil in the Details
Yufeng Zhang*, Richard J. Miron
Over 15 years has now passed since enamel matrix derivative (EMD) was shown to facilitate periodontal regeneration by stimulating new cementum, alveolar bone and periodontal ligament formation. The major component of EMD is a family of hydrophobic proteins,amelogenins, which account for more than 95% of the total protein content of the enamel matrix.
Haplotypes of Susceptibility to Chronic Periodontitis do not Influence MMP-8 Levels or the Outcome of Non-Surgical Periodontal Therapy
Giovana Anovazzi, Marcell C. de Medeiros, Túlio M. Ferrisse, Sâmia C. T. Corbi, Livia S. Finoti, Márcia Hiromi Tanaka, Andrea M. Marcaccini, Silvana R. P. Orrico, Joni A. Cirelli, Raquel F. Gerlach, Raquel M. Scarel-Caminaga *
Chronic periodontitis (CP) is a multifactorial condition, presenting immunoinflammatory reaction, in which a myriad of molecules including cytokines and matrix metalloproteinases (MMPs) interplays, making the system extremely intricate. There is scarce information regarding interconnections of biological influence among IL-4, IL-8 and MMP-8,mainly considering genetic polymorphisms, and also, whether this can influence the outcome of periodontal therapy.
Molecular Mechanism of Cranial Neural Crest Cell Development
Akiko Suzuki, Dhruvee R. Sangani, Junichi Iwata*
The craniofacial region, comprising the face and the skull, is largely the product of cranial neural crest (CNC) cells, in which CNC cells form most of the bone, cartilage and connective tissues. Genetic mutations, environmental factors, and nutritional deficiencies have been identified as risk factors to affect the fate of CNC cells and cause craniofacial deformities. Many signaling pathways and their interactions are involved in the formation of CNC derivatives and disturbances of these cascades are attributed as etiological agents for craniofacial pathologies.
Catechol O-Methyltransferase: A Review of the Gene and Enzyme
Neil R. McGregor*
Genetic polymorphisms in the Catechol O-Methyltransferase (COMT) gene have been linked to increased pain sensitivity ina number of studies. A literature search was performed to integrate the current knowledge of the gene, its regulation, influencesof the polymorphisms upon enzyme function and its population distributions. Assessment also includes the currentknowledge of the enzyme structure, isoforms, function and metabolic activities, substrates, and products. Other gene polymorphisms which may influence the components involved within the COMT enzymatic reaction, such as folate metabolism polymorphisms and cofactor availability, were also briefly assessed.
Digital Dynanometer for Cementation and its Influence on the Film Thickness of Ceramic Restorations
Marcelo Taveira Barbosa*, Mauro A. Caldeira de Andrada, Luiz Clovis Cardoso Vieira, Luiz Narciso Baratieri
The aim of this study was to develop a standardization technique of cementation force. Firstly, a digital dynamometer for clinical application was developed for standardization of the cementation force. Next, the accuracy of the dynamometer was verified through a comparative evaluation of the internal adaptation of all-ceramic crowns cemented under digital force or using the device.