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September 2014  

Volume 1 Issue 1

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Research Article

Relationship between Otologic Symptoms, Headache, Depression and Temporomandibular Disorders

Rahena Akhter*, Nur Mohammad Monsur Hassan, Manabu Morita, and David Wilson

The etiology of temporomandibular disorder (TMD) is largely unknown. Some studies have been implicated that otologic symptoms are associated with the predisposition, initiation, and perpetuation of TMD. The aim is to investigate the associations of aural symptoms, headache and depression with the presence of TMD symptoms in young adults.                                                                                                     

                                                                                                                                                             Download PDF Full text

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Editorial

The Arrival of Synthetic Bone Grafts with Osteoinductive Potential

Richard J. Miron*, Yufeng Zhang

Bone grafting materials have played a pivotal role in modern dentistry. Used to fill bone defects and to augment missing or lost bone, a wide variety of bone grafts are now available including autogenous bone from the same donor, allografts harvested from human donors, xenografts harvested from an animal donor and a wide variety of synthetically fabricated bone grafts made from hydroxyappatite, tri-calcium phosphate, biphasic calcium phosphate and bioactive glasses.                                                                                                     

                                                                                                                                                             Download PDF Full text

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 Editorial

 Adsorption of Enamel Matrix Derivative to Bone Grafts: Is the Devil in the Details

Yufeng Zhang*, Richard J. Miron

Over 15 years has now passed since enamel matrix derivative (EMD) was shown to facilitate periodontal regeneration by stimulating new cementum, alveolar bone and periodontal ligament formation. The major component of EMD is a family of hydrophobic proteins,amelogenins, which account for more than 95% of the total protein content of the enamel matrix.                                                                                             

                                                                                                                                                             Download PDF Full text

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Research Article

Haplotypes of Susceptibility to Chronic Periodontitis do not Influence MMP-8 Levels or the Outcome of Non-Surgical Periodontal Therapy

Giovana Anovazzi, Marcell C. de Medeiros, Túlio M. Ferrisse, Sâmia C. T. Corbi, Livia S. Finoti, Márcia Hiromi Tanaka, Andrea M. Marcaccini, Silvana R. P. Orrico, Joni A. Cirelli, Raquel F. Gerlach, Raquel M. Scarel-Caminaga *

Chronic periodontitis (CP) is a multifactorial  condition, presenting immunoinflammatory reaction, in  which a myriad of molecules including cytokines and  matrix metalloproteinases (MMPs) interplays, making the system extremely intricate. There is scarce information regarding interconnections of biological influence among IL-4, IL-8 and MMP-8,mainly considering genetic polymorphisms, and also, whether this can influence the outcome of periodontal therapy.                                                                                                     

                                                                                                                                                              Download PDF Full text __________________________________________________________________________________________

Review Article

Molecular Mechanism of Cranial Neural Crest Cell Development

Akiko Suzuki, Dhruvee R. Sangani, Junichi Iwata*

The craniofacial region, comprising  the face  and the skull, is largely the  product of cranial  neural crest (CNC) cells, in  which CNC cells  form most of the bone,  cartilage and connective  tissues. Genetic mutations, environmental factors, and nutritional deficiencies have been identified as risk factors to affect the fate of CNC cells and cause craniofacial deformities. Many signaling pathways and their interactions are involved in the formation of CNC derivatives and disturbances of these cascades are attributed as etiological agents for craniofacial pathologies.                                                                         

                                                                                                                                                             Download PDF Full text

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Research Article

Catechol O-Methyltransferase: A Review of the Gene and Enzyme

Neil R. McGregor*

Genetic polymorphisms in the Catechol O-Methyltransferase (COMT) gene have been linked to increased pain sensitivity ina number of studies. A literature search was performed to integrate the current knowledge of the gene, its regulation, influencesof the polymorphisms upon enzyme function and its population distributions. Assessment also includes the currentknowledge of the enzyme structure, isoforms, function and metabolic activities, substrates, and products. Other gene polymorphisms which may influence the components involved within the COMT enzymatic reaction, such as folate metabolism polymorphisms and cofactor availability, were also briefly assessed.                                                                         

 

                                                                                                                                                             Download PDF Full text __________________________________________________________________________________________

Research Article

Digital Dynanometer for Cementation and its Influence on the Film Thickness of Ceramic Restorations
Marcelo Taveira Barbosa*, Mauro A. Caldeira de Andrada, Luiz Clovis Cardoso Vieira, Luiz Narciso Baratieri

The aim of this study was to develop a standardization technique of cementation force. Firstly, a digital dynamometer for clinical application was developed for standardization of the cementation force. Next, the accuracy of the dynamometer was verified through a comparative evaluation of the internal adaptation of all-ceramic crowns cemented under digital force or using the device.    

 

                                                                                                                                                             Download PDF Full text

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